The AVERETT Lab
Advancing the Vitality of bioEngineering Research and Education through Multiscale Technologies and Transformations
1. Computational Studies of Fibrin Clots
We have developed several computational methods to evaluate fibrin clots at various length scales. Recently, we developed a novel reactive coarse grain molecular dynamics method to simulate the formation of fibrin clots from fibrinogen in the presence of thrombin and factor XIIIa. The method can be extended to simulate the fibrin clotting mechanism and can be used to predict the mechanical properties of fibrin clots in normal and pathological states.
2. Microscopy Analysis of Fibrin Clots
We are working toward the characterization of fibrin clots using microscopy techniques to determine fiber formation and morphology under various physiological conditions.
3. Fibrin Clot Mechanical Properties Estimation from Experiments
Understanding the mechanical properties associated with the blood clots for patients with diabetes and sickle cell disease is of great importance. Accurate thrombolytic therapies can be developed with this understanding. Currently, we are characterizing fibrin clots with inclusions using rheology and other material characterization methods.
Matlab Codes
click here for the MATLAB files used in the paper "Glucose Concentration Affects Fibrin Clot Structure and Morphology as Evidenced by Fluorescence Imaging and Molecular Simulations"